ARMC5-CUL3 E3 ligase targets full-length SREBF in adrenocortical tumors.

Abstract excerpt

Inactivating mutations of ARMC5 are responsible for the development of bilateral macronodular adrenal hyperplasia (BMAH). Although ARMC5 inhibits adrenocortical tumor growth and is considered a tumor-suppressor gene, its molecular function is poorly understood. In this study, through biochemical purification using SREBF (SREBP) as bait, we identified the interaction between SREBF and ARMC5 through its Armadillo...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Armadillo Domain Proteins
• Share to Germ-Line Mutation
• Share to Mutation