Requirement of N-terminal cysteines of PSD-95 for PSD-95 multimerization and ternary complex formation, but not for binding to potassium channel Kv1.4.

doi:10.1074/jbc.274.1.532

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Article

Requirement of N-terminal cysteines of PSD-95 for PSD-95 multimerization and ternary complex formation, but not for binding to potassium channel Kv1.4.

The Journal of biological chemistry - 1 Jan 1999

Hsueh Y P, Sheng M

Abstract excerpt

The PSD-95 family of PSD-95/Discs large/ZO-1 (PDZ) domain-containing proteins plays a role in the clustering and localization of specific ion channels and receptors at synapses. Previous studies have shown that PSD-95 forms multimers through an N-terminal region (termed the N-segment) and that th...

Topics

Animals
Biopolymers
COS Cells
Cysteine
Guanylate Kinases
Kv1.4 Potassium Channel
Mutation
Nucleoside-Phosphate Kinase
Potassium Channels
Potassium Channels, Voltage-Gated
Protein Binding

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