Article
Immunologic hierarchy, class II MHC promiscuity, and epitope spreading of a melanoma helper peptide vaccine.
Cancer immunology, immunotherapy : CII - 1 Aug 2014
Hu Yinin, Petroni Gina R, Olson Walter C, Czarkowski Andrea, Smolkin Mark E, Grosh William W, Chianese-Bullock Kimberly A, Slingluff Craig L
Abstract excerpt
Immunization with a combination melanoma helper peptide (6MHP) vaccine has been shown to induce CD4(+) T cell responses, which are associated with patient survival. In the present study, we define the relative immunogenicity and HLA allele promiscuity of individual helper peptides and identify helper peptide-mediated augmentation of specific CD8(+) T cell responses. Thirty-seven participants with stage IIIB-IV...
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