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Article

The Role of Stat4 in Species-Specific Regulation of Th Cell Development by Type I IFNs

1 Dec 1998

Abstract excerpt

Type I IFNs (IFN-alpha/beta), in addition to IL-12, have been shown to play an important role in the differentiation of human, but not mouse, Th cells. We show here that IFN-alpha/beta act directly on human T cells to drive Th1 development, bypassing the need for IL-12-induced signaling, whereas IFN-alpha cannot substitute IL-12 for mouse Th1 development. The molecular basis for this species specificity is that...

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PMID: 9862683
DOI: 10.4049/jimmunol.161.12.6567

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