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Article

GATA3 up-regulation associated with surface expression of CD294/CRTH2: a unique feature of human Th cells

18 Jan 2007

Abstract excerpt

GATA-3 and T-box expressed in T cells (T-bet) play central roles in Th-cell development and function. Consistently, studies in mice document their selective expression in Th1 and Th2 cells, respectively. In contrast, it is not clear whether these genes are regulated in human Th cells. Here we show that T-bet expression is polarized to a comparable degree in human and mouse Th-cell cultures, while only mouse GATA3...

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PMID: 17234745
DOI: 10.1182/blood-2006-05-025940

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