Article
IL-12-induced reversal of human Th2 cells is accompanied by full restoration of IL-12 responsiveness and loss of GATA-3 expression.
European journal of immunology - 1 Apr 2001
Smits H H, van Rietschoten J G, Hilkens C M, Sayilir R, Stiekema F, Kapsenberg M L, Wierenga E A
Abstract excerpt
IL-12 is a potent inducer of IFN-gamma production and drives the development of Th1 cells. Human polarized Th2 cells do not express the signaling beta2-subunit of the IL-12R and, therefore, do not signal in response to IL-12. The question was raised as to what extent the loss of the IL-12Rbeta2 chain in Th2 cells has bearing on the stability of the human Th2 phenotype. In the present report, we show that...
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