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Article

IL-12-induced reversal of human Th2 cells is accompanied by full restoration of IL-12 responsiveness and loss of GATA-3 expression.

European journal of immunology - 1 Apr 2001

Smits H H, van Rietschoten J G, Hilkens C M, Sayilir R, Stiekema F, Kapsenberg M L, Wierenga E A

Abstract excerpt

IL-12 is a potent inducer of IFN-gamma production and drives the development of Th1 cells. Human polarized Th2 cells do not express the signaling beta2-subunit of the IL-12R and, therefore, do not signal in response to IL-12. The question was raised as to what extent the loss of the IL-12Rbeta2 c...

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PMID: 11298330
DOI: 10.1002/1521-4141(200104)31:4<1055::aid-immu1055>3.0.co;2-7

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STAT4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11298330-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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