MDM2 amplification and loss of heterozygosity at Rb and p53 genes: no simultaneous alterations in the oncogenesis of liposarcomas.

doi:10.1007/s004320050211

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Article

MDM2 amplification and loss of heterozygosity at Rb and p53 genes: no simultaneous alterations in the oncogenesis of liposarcomas.

Journal of cancer research and clinical oncology - 1 Jan 1998

Schneider-Stock R, Walter H, Radig K, Rys J, Bosse A, Kuhnen C, Hoang-Vu C, Roessner A

Abstract excerpt

PURPOSE: The present study aimed to investigate the status of alterations of the MDM2, Rb and p53 genes in a series of 45 liposarcomas. Furthermore, the possible correlation with histological and clinical parameters was studied. METHODS: MDM2 amplification was examined by non-radioactive Southern...

Topics

Adult
Aged
Aged, 80 and over
Blotting, Southern
Female
Gene Amplification
Genes, Retinoblastoma
Genes, p53
Humans
Liposarcoma
Loss of Heterozygosity
Male
Middle Aged
Mutation
Nuclear Proteins
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Proto-Oncogene Proteins

Source

Open in PubMed

Identifiers

PMID: 9829856
DOI: 10.1007/s004320050211

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9829856-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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