Article
Differential reactivity of brain microvascular endothelial cells to TNF reflects the genetic susceptibility to cerebral malaria.
European journal of immunology - 1 Dec 1998
Lou J, Gasche Y, Zheng L, Critico B, Monso-Hinard C, Juillard P, Morel P, Buurman W A, Grau G E
Abstract excerpt
Upon infection with Plasmodium berghei ANKA (PbA), various inbred strains of mice exhibit different susceptibility to the development of cerebral malaria (CM). Tumor necrosis factor-alpha (TNF) and interferon-gamma (IFN-gamma) have been shown to be crucial mediators in the pathogenesis of this ne...
Topics
- Animals
- Brain
- E-Selectin
- Endothelium, Vascular
- Genetic Predisposition to Disease
- Intercellular Adhesion Molecule-1
- Interleukin-6
- Malaria, Cerebral
- Mice
- Mice, Inbred Strains
- Microcirculation