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Article

Protein kinase C θ deficiency increases resistance of C57BL/6J mice to Plasmodium berghei infection-induced cerebral malaria.

Infection and immunity - 1 Oct 2010

Ohayon Ariel, Golenser Jacob, Sinay Rosa, Tamir Ami, Altman Amnon, Pollack Yaakov, Isakov Noah

Abstract excerpt

Protein kinase C θ (PKCθ) functions as a core component of the immunological synapse and serves as a key protein in the integrated T-cell antigen receptor (TCR)/CD28-induced signaling cascade leading to T-cell activation. However, the involvement of PKCθ in host-mediated immune responses to pathogens has not been thoroughly investigated. We tested the consequences of PKCθ ablation on the host response to...

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Source

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Identifiers

PMID: 20660606
DOI: 10.1128/IAI.00465-10
PMCID: PMC2950346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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