Article
No evidence for involvement of the leptin gene in anorexia nervosa, bulimia nervosa, underweight or early onset extreme obesity: identification of two novel mutations in the coding sequence and a novel polymorphism in the leptin gene linked upstream region.
Molecular psychiatry - 1 Nov 1998
Hinney A, Bornscheuer A, Depenbusch M, Mierke B, Tölle A, Middeke K, Ziegler A, Roth H, Gerber G, Zamzow K, Ballauff A, Hamann A, Mayer H, Siegfried W, Lehmkuhl G, Poustka F, Schmidt M H, Hermann H, Herpertz-Dahlmann B M, Fichter M, Remschmidt H, Hebebrand J
Abstract excerpt
Mutations in the leptin gene can result in profound obesity in both rodents and humans. In humans, serum leptin levels correlate with body mass index (BMI: kg m(-2)). However, in patients with anorexia nervosa (AN) leptin levels are lower than in BMI-matched healthy controls. We had previously ar...
Topics
- Adolescent
- Age of Onset
- Amino Acid Substitution
- Anorexia Nervosa
- Body Mass Index
- Body Weight
- Bulimia
- Child
- Gene Frequency
- Genotype