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Article

Leptin receptor gene variation and obesity: lack of association in a white British male population.

Human molecular genetics - 1 Jun 1997

Gotoda T, Manning B S, Goldstone A P, Imrie H, Evans A L, Strosberg A D, McKeigue P M, Scott J, Aitman T J

Abstract excerpt

Leptin, a hormone secreted by adipocytes, plays a pivotal role in the control of body weight. Rodents with mutations in the leptin receptor gene develop morbid obesity. It is possible, therefore, that leptin receptor gene mutations contribute to human obesity. To test this possibility, we determined the entire coding sequence of the human leptin receptor cDNA from peripheral blood lymphocytes of 22 morbidly obese...

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Identifiers

PMID: 9175732
DOI: 10.1093/hmg/6.6.869

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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