Article
Identification of new sequence variants in the leptin gene.
The Journal of clinical endocrinology and metabolism - 1 Sept 1998
Karvonen M K, Pesonen U, Heinonen P, Laakso M, Rissanen A, Naukkarinen H, Valve R, Uusitupa M I, Koulu M
Abstract excerpt
The leptin gene (LEP) has been linked to extreme obesity. However, no common obesity-related gene variants have been found to exist in the LEP. The present study was designed to investigate the LEP for variants by screening both the putative promoter and the coding region of this gene in obese Fi...
Topics
- Adult
- Body Mass Index
- DNA
- Finland
- Gene Frequency
- Humans
- Leptin
- Middle Aged
- Mutation
- Obesity
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Promoter Regions, Genetic
- Proteins