Article
Systematic mutation screening of the estrogen receptor beta gene in probands of different weight extremes: identification of several genetic variants.
The Journal of clinical endocrinology and metabolism - 1 Dec 1998
Rosenkranz K, Hinney A, Ziegler A, Hermann H, Fichter M, Mayer H, Siegfried W, Young J K, Remschmidt H, Hebebrand J
Abstract excerpt
Estrogens are known to have an inhibitory effect on food intake in rodents and primates. Decreased estrogen levels that are found for instance in menopausal woman and in ovarectomized rodents result in body weight gain. Estrogen can act both in the periphery and in the central nervous system via at least two different estrogen receptors (alpha and beta). We systematically screened the coding region and part of...
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