A common pentanucleotide polymorphism of the 3'-untranslated part of the leptin receptor gene generates a putative stem-loop motif in the mRNA and is associated with serum insulin levels in obese individuals.

doi:10.1038/sj.ijo.0800639

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Article

A common pentanucleotide polymorphism of the 3'-untranslated part of the leptin receptor gene generates a putative stem-loop motif in the mRNA and is associated with serum insulin levels in obese individuals.

International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity - 1 Jul 1998

Oksanen L, Kaprio J, Mustajoki P, Kontula K

Abstract excerpt

OBJECTIVE: To find out whether genetic alterations of the leptin receptor gene underlie human forms of obesity. DESIGN: Among 249 morbidly obese adults (body mass index, BMI > or = 40 kg/m2), we screened 30 patients with the highest serum leptin levels for alterations of their leptin receptor gen...

Topics

Adult
Carrier Proteins
Female
Genotype
Humans
Insulin
Leptin
Male
Microsatellite Repeats
Middle Aged
Nucleic Acid Conformation
Obesity
Polymorphism, Single-Stranded Conformational
Proteins

Source

Open in PubMed

Identifiers

PMID: 9705022
DOI: 10.1038/sj.ijo.0800639

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9705022-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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