Hb Montefiore (126(H9)Asp-->Tyr). High oxygen affinity and loss of cooperativity secondary to C-terminal disruption.

doi:10.1074/jbc.271.38.22990

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Article

Hb Montefiore (126(H9)Asp-->Tyr). High oxygen affinity and loss of cooperativity secondary to C-terminal disruption.

The Journal of biological chemistry - 20 Sept 1996

Wajcman H, Kister J, Galactéros F, Spielvogel A, Lin M J, Vidugiris G J, Hirsch R E, Friedman J M, Nagel R L

Abstract excerpt

Hb Montefiore was found, in the heterozygous state, in a Puerto Rican female who had a slightly elevated total Hb level. Structural analysis revealed that Asp-alpha126 was replaced by Tyr. Hb Montefiore migrates close to HbF (at pH 8.6) and accounts for 20.3% of the hemolysate. Oxygen binding of...

Topics

Allosteric Regulation
Aspartic Acid
Chromatography, High Pressure Liquid
Erythrocytes
Female
Hemoglobins, Abnormal
Heterozygote
Humans
Infant, Newborn
Mutation
Oxygen
Puerto Rico
Spectrometry, Fluorescence
Spectrum Analysis, Raman
Tyrosine

Source

Open in PubMed

Identifiers

PMID: 8798486
DOI: 10.1074/jbc.271.38.22990

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8798486-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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