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Article

Gene duplication and the evolution of hemoglobin isoform differentiation in birds.

The Journal of biological chemistry - 2 Nov 2012

Grispo Michael T, Natarajan Chandrasekhar, Projecto-Garcia Joana, Moriyama Hideaki, Weber Roy E, Storz Jay F

Abstract excerpt

The majority of bird species co-express two functionally distinct hemoglobin (Hb) isoforms in definitive erythrocytes as follows: HbA (the major adult Hb isoform, with α-chain subunits encoded by the α(A)-globin gene) and HbD (the minor adult Hb isoform, with α-chain subunits encoded by the α(D)-globin gene). The α(D)-globin gene originated via tandem duplication of an embryonic α-like globin gene in the stem...

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Identifiers

PMID: 22962007
DOI: 10.1074/jbc.M112.375600
PMCID: PMC3488042

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