Article
Analysis of the CDKN2A, CDKN2B and CDK4 genes in 48 Australian melanoma kindreds.
Oncogene - 11 Dec 1997
Flores J F, Pollock P M, Walker G J, Glendening J M, Lin A H, Palmer J M, Walters M K, Hayward N K, Fountain J W
Abstract excerpt
Germline mutations within the cyclin-dependent kinase inhibitor 2A (CDKN2A) gene and one of its targets, the cyclin dependent kinase 4 (CDK4) gene, have been identified in a proportion of melanoma kindreds. In the case of CDK4, only one specific mutation, resulting in the substitution of a cysteine for an arginine at codon 24 (R24C), has been found to be associated with melanoma. We have previously reported the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.