Article
Analysis of the CDKN2A, CDKN2B and CDK4 genes in 48 Australian melanoma kindreds.
Oncogene - 11 Dec 1997
Flores J F, Pollock P M, Walker G J, Glendening J M, Lin A H, Palmer J M, Walters M K, Hayward N K, Fountain J W
Abstract excerpt
Germline mutations within the cyclin-dependent kinase inhibitor 2A (CDKN2A) gene and one of its targets, the cyclin dependent kinase 4 (CDK4) gene, have been identified in a proportion of melanoma kindreds. In the case of CDK4, only one specific mutation, resulting in the substitution of a cystei...
Topics
- Alleles
- Alternative Splicing
- Australia
- Cyclin-Dependent Kinases
- DNA Mutational Analysis
- Disease Susceptibility
- Genes, p16
- Genetic Linkage
- Genetic Markers
- Genetic Testing
- Haplotypes
- Humans
- Melanoma
- Mutation
- Pedigree
- Polymorphism, Single-Stranded Conformational
- Transcription, Genetic