Article
Mutation screening of the CDKN2A promoter in melanoma families.
Genes, chromosomes & cancer - 1 May 2000
Harland M, Holland E A, Ghiorzo P, Mantelli M, Bianchi-Scarrà G, Goldstein A M, Tucker M A, Ponder B A, Mann G J, Bishop D T, Newton Bishop J
Abstract excerpt
Germline mutations of CDKN2A, at 9p21, are responsible for predisposition to melanoma in some families. However, evidence of linkage to 9p21 has been demonstrated in a significant proportion of kindreds with no detectable mutations in CDKN2A. It is possible that mutations in noncoding regions may be responsible for predisposition to melanoma in these families. We have analyzed approximately 1 kb of the CDKN2A...
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