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Article

Mutation of the CDKN2A 5' UTR creates an aberrant initiation codon and predisposes to melanoma.

Nature genetics - 1 Jan 1999

Liu L, Dilworth D, Gao L, Monzon J, Summers A, Lassam N, Hogg D

Abstract excerpt

Approximately 8-12% of melanoma is inherited in an autosomal dominant fashion with variable penetrance. A chromosome 9p21 locus has been linked to this disease in 50-80% of affected families. CDKN2A (also known as P16, INK4, p16INK4A and MTS1) is allelic to this locus and encodes a cdk4/cdk6 kinase inhibitor that constrains cells from progressing through the G1 restriction point. Although germline CDKN2A coding...

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PMID: 9916806
DOI: 10.1038/5082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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