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Article

Multiple genetic loci modify risk for retinoblastoma in transgenic mice.

Investigative ophthalmology & visual science - 1 Dec 1998

Griep A E, Krawcek J, Lee D, Liem A, Albert D M, Carabeo R, Drinkwater N, McCall M, Sattler C, Lasudry J G, Lambert P F

Abstract excerpt

PURPOSE: Forty percent of cases of retinoblastoma, a childhood malignancy of the retina, are linked to the inheritance of a mutant allele of the retinoblastoma susceptibility gene Rb1. Tumor penetrance varies among carriers in different family pedigrees, indicating that other genetic factors may modify risk for occurrence of retinoblastoma. This study was undertaken to determine whether multiple genetic loci...

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PMID: 9856783

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