Article
Multiple genetic loci modify risk for retinoblastoma in transgenic mice.
Investigative ophthalmology & visual science - 1 Dec 1998
Griep A E, Krawcek J, Lee D, Liem A, Albert D M, Carabeo R, Drinkwater N, McCall M, Sattler C, Lasudry J G, Lambert P F
Abstract excerpt
PURPOSE: Forty percent of cases of retinoblastoma, a childhood malignancy of the retina, are linked to the inheritance of a mutant allele of the retinoblastoma susceptibility gene Rb1. Tumor penetrance varies among carriers in different family pedigrees, indicating that other genetic factors may...
Topics
- Animals
- Antigens, Polyomavirus Transforming
- DNA Primers
- DNA-Binding Proteins
- Female
- Genotype
- In Situ Hybridization
- Male
- Mice
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Mice, Transgenic
- Oncogene Proteins, Viral
- Papillomaviridae
- Papillomavirus E7 Proteins