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Article

Molecular Signature of HPV-Induced Carcinogenesis: pRb, p53 and Gene Expression Profiling

1 Mar 2009

Abstract excerpt

The infection by mucosal human papillomavirus (HPV) is causally associated with tumor development in cervix and oropharynx. The mechanisms responsible for this oncogenic potential are mainly due to the product activities of two early viral oncogenes: E6 and E7. Although a large number of cellular targets have been described for both oncoproteins, the interaction with tumor suppressors p53 and retinoblastoma...

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PMID: 19721808
DOI: 10.2174/138920209787581235

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