Article
Quantitative effects of the retinoblastoma gene on mouse development and tissue-specific tumorigenesis.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Dec 1993
Chang C Y, Riley D J, Lee E Y, Lee W H
Abstract excerpt
Models for studying the quantitative effects of RB protein in development and in tumorigenesis have been constructed. By crossing transgenic mice carrying the human Rb gene with mice heterozygous for the normal mouse Rb gene, we have generated mice that contain varying copies of the human Rb tran...
Topics
- Animals
- Embryonic and Fetal Development
- Genes, Retinoblastoma
- Genetic Complementation Test
- Genetic Predisposition to Disease
- Genotype
- Heterozygote
- Humans
- Mice
- Mice, Transgenic
- Neoplasms, Experimental
- Organ Specificity
- Phenotype
- Retinoblastoma Protein