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Article

Quantitative effects of the retinoblastoma gene on mouse development and tissue-specific tumorigenesis.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Dec 1993

Chang C Y, Riley D J, Lee E Y, Lee W H

Abstract excerpt

Models for studying the quantitative effects of RB protein in development and in tumorigenesis have been constructed. By crossing transgenic mice carrying the human Rb gene with mice heterozygous for the normal mouse Rb gene, we have generated mice that contain varying copies of the human Rb transgene and express varying amounts of human RB protein. Herein, we show that different amounts of RB protein are...

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PMID: 8117619

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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