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Article

Disrupted Calcium Signaling in Animal Models of Human Spinocerebellar Ataxia (SCA)

27 Dec 2019

Abstract excerpt

Spinocerebellar ataxias (SCAs) constitute a heterogeneous group of more than 40 autosomal-dominant genetic and neurodegenerative diseases characterized by loss of balance and motor coordination due to dysfunction of the cerebellum and its efferent connections. Despite a well-described clinical and pathological phenotype, the molecular and cellular events that underlie neurodegeneration are still poorly...

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PMID: 31892274
DOI: 10.3390/ijms21010216

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