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Article

Lycopene in the prevention of renal cell cancer in the TSC2 mutant Eker rat model.

Archives of biochemistry and biophysics - 15 Apr 2015

Sahin Kazim, Cross Brian, Sahin Nurhan, Ciccone Karina, Suleiman Shadeah, Osunkoya Adeboye O, Master Viraj, Harris Wayne, Carthon Bradley, Mohammad Ramzi, Bilir Birdal, Wertz Karin, Moreno Carlos S, Walker Cheryl L, Kucuk Omer

Abstract excerpt

Renal cell carcinoma (RCC) is the most frequent upper urinary tract cancer in humans and accounts for 80-85% of malignant renal tumors. Eker rat represents a unique animal model to study RCC since these rats develop spontaneous renal tumors and leiomyoma, which may be due to tuberous sclerosis 2 (TSC2) mutation resulting in the activation of the mammalian target of rapamycin (mTOR) pathway. This study examines...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25602702
DOI: 10.1016/j.abb.2015.01.006
PMCID: PMC5657428

Genes

TSC2
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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