Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thyroid follicular oncogenesis in iodine-deficient and iodine-sufficient areas: search for alterations of the ras, met and bFGF oncogenes and of the Rb anti-oncogene.

Journal of endocrinological investigation - 1 Nov 1998

Bartolone L, Vermiglio F, Finocchiaro M D, Violi M A, French D, Pontecorvi A, Trimarchi F, Benvenga S

Abstract excerpt

To gain insights into the role of iodine deficiency in favoring thyroid tumorigenesis (particularly of the follicular histotype), 22 Sicilian patients with thyroid tumors were selected for having lived permanently in either one of two areas of different iodine availability. Eleven patients (age 46.1 +/- 14.6 years, mean +/- SD; 10 females and 1 male) were from the iodine-deficient (ID) areas of the provinces of...

Topics

Adult
Aged
Female
Fibroblast Growth Factor 2
Genes, ras
Humans
Iodine
Male
Middle Aged
Mutation
Proto-Oncogene Proteins c-met

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Retinoblastoma Protein

Sicily

Thyroid Neoplasms

Source

Identifiers

PMID: 9854684
DOI: 10.1007/BF03350798

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thyroid follicular oncogenesis in iodine-deficient and iodine-sufficient areas: search for alterations of the ras, met and bFGF oncogenes and of the Rb anti-oncogene.PMID 9854684Read ↗

<i>RAS</i>Point Mutations and PAX8-PPARγ Rearrangement in Thyroid Tumors: Evidence for Distinct Molecular Pathways in Thyroid Follicular CarcinomaSemantic proximity Read ↗

Genetic background of carcinogenesis in the thyroid gland.Semantic proximity Read ↗

Pathogenesis of toxic thyroid adenomas and nodules: relevance of activating mutations in the TSH-receptor and Gs-alpha gene, the possible role of iodine deficiency and secondary and TSH-independent molecular mechanisms.Semantic proximity Read ↗

Effect of iodine on early stage thyroid autonomy.Semantic proximity Read ↗

High rates of ras codon 61 mutation in thyroid tumors in an iodide-deficient area.Semantic proximity Read ↗

N-ras mutation of thyroid tumor with special reference to the follicular type.Semantic proximity Read ↗

Gain of function TSH receptor mutations and iodine deficiency: implications in iodine prophylaxis.Semantic proximity Read ↗

Down-regulation of microRNAs controlling tumourigenic factors in follicular thyroid carcinoma.Semantic proximity Read ↗

[Mutations in the thyrotropin receptor gene in the pathogenesis of toxic thyroid adenomas, toxic goiter nodules and autosomal dominant hyperthyroidism].Semantic proximity Read ↗

Prevalence of mutations in TSHR, GNAS, PRKAR1A and RAS genes in a large series of toxic thyroid adenomas from Galicia, an iodine-deficient area in NW Spain.Semantic proximity Read ↗

RET/PTC rearrangement is prevalent in follicular Hürthle cell carcinomas.Semantic proximity Read ↗

Biological activity of activating thyrotrophin receptor mutants: modulation by iodide.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.