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Article

High rates of ras codon 61 mutation in thyroid tumors in an iodide-deficient area.

Cancer research - 15 May 1991

Shi Y F, Zou M J, Schmidt H, Juhasz F, Stensky V, Robb D, Farid N R

Abstract excerpt

Using polymerase chain reaction and sequence-specific oligonucleotide hybridization, the frequency of three ras oncogene mutations (N-ras, Ha-ras, and K-ras) in thyroid tumors (25 adenomas, 16 follicular carcinomas, and 22 papillary carcinomas) was investigated in both iodide-deficient and iodide-sufficient areas. The ras oncogene mutation rate was significantly higher in the iodide-deficient area, being 85...

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PMID: 2021946

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