Article
RET/PTC rearrangement is prevalent in follicular Hürthle cell carcinomas.
Histopathology - 1 Nov 2012
de Vries Margriet M, Celestino Ricardo, Castro Patricia, Eloy Catarina, Máximo Valdemar, van der Wal Jacqueline E, Plukker John T M, Links Thera P, Hofstra Robert M W, Sobrinho-Simões Manuel, Soares Paula
Abstract excerpt
AIMS: The molecular alterations underlying follicular Hürthle cell carcinomas (FHCCs) are largely unknown. In an attempt to clarify this issue, we analysed a series of Hürthle cell tumours for the presence of RET/PTC and PAX8/PPARG rearrangements and BRAF, HRAS and NRAS mutations. METHODS AND RESULTS: We investigated a series of 20 follicular Hürthle cell tumours [17 FHCCs and three follicular Hürthle cell...
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