Article
Reduction of platelet phospholipase C-delta1 activity in Alzheimer's disease associated with a specific apolipoprotein E genotype (epsilon3/epsilon3).
International journal of molecular medicine - 1 Jan 1998
Matsushima H, Shimohama S, Kawamata J, Fujimoto S, Takenawa T, Kimura J
Abstract excerpt
The epsilon4 allele of apolipoprotein E (apo E) is increased among patients with sporadic or familial Alzheimer's disease (AD). We examined platelet phospholipase C (PLC)-delta1 activity in AD patients either homozygous for apoepsilon3 or having at least one apo epsilon4 allele. We found that pla...
Topics
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Apolipoprotein E3
- Apolipoprotein E4
- Apolipoproteins E
- Blood Platelets
- Female
- Genotype
- Humans
- Isoenzymes
- Male
- Oxidation-Reduction
- Phospholipase C delta
- Type C Phospholipases