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Article

Interaction between the APOE epsilon4 allele and the APH-1b c + 651T > G SNP in Alzheimer's disease.

Neurobiology of aging - 1 Oct 2008

Poli Maura, Gatta Luisa Benerini, Lovati Carlo, Mariani Claudio, Galimberti Daniela, Scarpini Elio, Biunno Ida, Musicco Massimo, Dominici Roberto, Albertini Alberto, Finazzi Dario

Abstract excerpt

The gamma-secretase complex is a multimeric aspartyl protease which plays a pivotal role in the production of amyloid beta-peptide, the main component of senile plaques in Alzheimer's disease (AD). APH-1a and APH-1b have been recently identified as important subunits of the gamma-secretase complex. We previously studied sequence variations in both genes and their association with AD in a small Italian population....

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Source

Identifiers

PMID: 17466415
DOI: 10.1016/j.neurobiolaging.2007.03.019

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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