Article
Opposite effects of plasma homocysteine and the methylenetetrahydrofolate reductase C677T mutation on carotid artery geometry in asymptomatic adults.
Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 1998
Demuth K, Moatti N, Hanon O, Benoit M O, Safar M, Girerd X
Abstract excerpt
Studies of symptomatic patients have identified hyperhomocysteinemia as an independent risk factor for vascular disease. In case-control studies, a point mutation (C677T) in the gene encoding 5,10-methylenetetrahydrofolate reductase (MTHFR) has also been linked to an increased risk of vascular di...
Topics
- Adult
- Aged
- Carotid Arteries
- Female
- Genotype
- Homocysteine
- Humans
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Multivariate Analysis
- Mutation