Article
Opposite effects of plasma homocysteine and the methylenetetrahydrofolate reductase C677T mutation on carotid artery geometry in asymptomatic adults.
Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 1998
Demuth K, Moatti N, Hanon O, Benoit M O, Safar M, Girerd X
Abstract excerpt
Studies of symptomatic patients have identified hyperhomocysteinemia as an independent risk factor for vascular disease. In case-control studies, a point mutation (C677T) in the gene encoding 5,10-methylenetetrahydrofolate reductase (MTHFR) has also been linked to an increased risk of vascular disease through its effect on homocysteinemia. Our aim was to extend these observations to asymptomatic subjects by...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.