Article
Molecular analysis of constitutive IL-1alpha gene expression in human melanoma cells: autocrine stimulation through NF-kappaB activation by endogenous IL-1alpha.
Cytokine - 1 Nov 1998
Kimura H, Inukai Y, Takii T, Furutani Y, Shibata Y, Hayashi H, Sakurada S, Okamoto T, Inoue J, Oomoto Y, Onozaki K
Abstract excerpt
Constitutive production of/and acquired resistance to anti-proliferative cytokines are implicated in pathogenesis and progression of human melanoma cells. Human melanoma cells A375-C6 are sensitive to interleukin 1 (IL-1) anti-proliferative effect and do not produce IL-1. After long period of cul...
Topics
- Autocrine Communication
- Gene Expression Regulation, Neoplastic
- Humans
- Interleukin-1
- Melanoma
- Mutation
- NF-kappa B
- Plasmids
- Transfection
- Tumor Cells, Cultured