Article
Association of persistent bronchial hyperresponsiveness with beta2-adrenoceptor (ADRB2) haplotypes. A population study.
American journal of respiratory and critical care medicine - 1 Dec 1998
D'amato M, Vitiani L R, Petrelli G, Ferrigno L, di Pietro A, Trezza R, Matricardi P M
Abstract excerpt
Bronchial hyperresponsiveness (BHR) is a hallmark of asthma and represents a strong risk factor for the disease. However, not all asthmatics have BHR and it can be observed in normal subjects too, probably because of genetic predisposition. Increasing attention is being focused on the beta2-adrenoceptor gene (ADRB2), whose genetic variability at amino acids 16 and 27 has been shown to correlate with some clinical...
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