Article
Vpx is required for dissemination and pathogenesis of SIV(SM) PBj: evidence of macrophage-dependent viral amplification.
Nature medicine - 1 Dec 1998
Hirsch V M, Sharkey M E, Brown C R, Brichacek B, Goldstein S, Wakefield J, Byrum R, Elkins W R, Hahn B H, Lifson J D, Stevenson M
Abstract excerpt
The viral accessory protein Vpx is required for productive in vitro infection of macrophages by simian immunodeficiency virus from sooty mangabey monkeys (SIV(SM)). To evaluate the roles of Vpx and macrophage infection in vivo, we inoculated pigtailed macaques intravenously or intrarectally with the molecularly cloned, macrophage tropic, acutely pathogenic virus SIV(SM) PBj 6.6, or accessory gene deletion mutants...
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