Article
Antigen activation and impaired Fas-induced death-inducing signaling complex formation in T-large-granular lymphocyte leukemia.
Blood - 1 Feb 2008
Yang Jun, Epling-Burnette P K, Painter Jeffrey S, Zou Jianxiang, Bai Fanqi, Wei Sheng, Loughran Thomas P
Abstract excerpt
Clonal T-cell expansion in patients with T-large-granular lymphocyte (LGL) leukemia occurs by an undefined mechanism that may be related to Fas apoptosis resistance. Here, we demonstrate polarized expansion of CD8(+) terminal-memory differentiation in such patients, as demonstrated by CD45RA expression and absence of CD62L expression, suggesting repeated stimulation by antigen in vivo. Elimination of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.