Article
Clonal osteoblastic cell lines from p53 null mouse calvariae are immortalized and dependent on bone morphogenetic protein 2 for mature osteoblastic phenotype.
Biochemical and biophysical research communications - 3 Feb 1997
Ghosh-Choudhury N, Harris M A, Wozney J, Mundy G R, Harris S E
Abstract excerpt
p53 protein regulates cell cycle progression and its absence will result in unlimited cell divisions required for immortalization of cells. Immortalized osteoblastic cell lines were established from p53 null mouse calvariae of normal phenotype. The clonal murine cell lines demonstrated osteoblast...
Topics
- Alkaline Phosphatase
- Animals
- Bone Morphogenetic Protein 2
- Bone Morphogenetic Proteins
- Calcification, Physiologic
- Cell Differentiation
- Cell Line
- Clone Cells
- Genes, p53
- Mice
- Osteoblasts
- Osteogenesis
- Phenotype
- Recombinant Proteins
- Stem Cells
- Transforming Growth Factor beta
- Tumor Suppressor Protein p53