Article
The akt kinase: molecular determinants of oncogenicity.
Proceedings of the National Academy of Sciences of the United States of America - 8 Dec 1998
Aoki M, Batista O, Bellacosa A, Tsichlis P, Vogt P K
Abstract excerpt
The serine-threonine kinase Akt is a downstream target of phosphoinositide 3-kinase (PI 3-kinase); it is activated by the phosphoinositide 3-phosphate-dependent kinases PDK1 and PDK2. Certain mutated forms of Akt induce oncogenic transformation in chicken embryo fibroblast cultures and hemangiosa...
Topics
- 3-Phosphoinositide-Dependent Protein Kinases
- Animals
- Base Sequence
- Cell Transformation, Neoplastic
- Chick Embryo
- Fibroblasts
- Hemangiosarcoma
- Molecular Sequence Data
- Mutation
- Neoplasms, Experimental
- Phosphatidylinositol 3-Kinases
- Protein Serine-Threonine Kinases
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-akt