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Article

The catalytic subunit of phosphoinositide 3-kinase: requirements for oncogenicity.

The Journal of biological chemistry - 3 Mar 2000

Aoki M, Schetter C, Himly M, Batista O, Chang H W, Vogt P K

Abstract excerpt

The retroviral oncogene p3k (v-p3k) of avian sarcoma virus 16 (ASV16) codes for the catalytic subunit of phosphoinositide (PI) 3-kinase, p110alpha. The v-P3k protein is oncogenic in vivo and in vitro; its cellular counterpart, c-P3k, lacks oncogenicity. Fusion of viral Gag sequences to the amino terminus of c-P3k activates the transforming potential. Activation can also be achieved by the addition of a...

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PMID: 10692423
DOI: 10.1074/jbc.275.9.6267

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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