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Article

Aberrant AKT activation drives well-differentiated liposarcoma.

Proceedings of the National Academy of Sciences of the United States of America - 27 Sept 2011

Gutierrez Alejandro, Snyder Eric L, Marino-Enriquez Adrian, Zhang Yi-Xiang, Sioletic Stefano, Kozakewich Elena, Grebliunaite Ruta, Ou Wen-Bin, Sicinska Ewa, Raut Chandrajit P, Demetri George D, Perez-Atayde Antonio R, Wagner Andrew J, Fletcher Jonathan A, Fletcher Christopher D M, Look A Thomas

Abstract excerpt

Well-differentiated liposarcoma (WDLPS), one of the most common human sarcomas, is poorly responsive to radiation and chemotherapy, and the lack of animal models suitable for experimental analysis has seriously impeded functional investigation of its pathobiology and development of effective targeted therapies. Here, we show that zebrafish expressing constitutively active Akt2 in mesenchymal progenitors develop...

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Identifiers

PMID: 21930930
DOI: 10.1073/pnas.1106127108
PMCID: PMC3182699

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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