Bax is an important determinant of chemosensitivity in pediatric tumor cell lines independent of Bcl-2 expression and p53 status.

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Article

Bax is an important determinant of chemosensitivity in pediatric tumor cell lines independent of Bcl-2 expression and p53 status.

Oncology research - 1 Jan 1998

McPake C R, Tillman D M, Poquette C A, George E O, Houghton J A, Harris L C

Abstract excerpt

Susceptibility of a tumor cell to undergo chemotherapy-induced apoptosis appears to be dependent upon the balance of proapoptotic and survival factors that are expressed within any given cell. We have chosen to evaluate how expression of several of these proteins influences chemosensitivity of a...

Topics

Animals
Apoptosis
Child
Glioma
Humans
Mutation
Neuroblastoma
Nuclear Proteins
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2
Proto-Oncogene Proteins c-mdm2
Rabbits
Rhabdomyosarcoma
Tumor Cells, Cultured
Tumor Suppressor Protein p53
bcl-2-Associated X Protein

Source

Open in PubMed

Identifiers

PMID: 9802058

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9802058-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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