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Article

Human gliomas with wild-type p53 express bcl-2.

Cancer research - 1 Mar 1995

Alderson L M, Castleberg R L, Harsh G R, Louis D N, Henson J W

Abstract excerpt

Human astrocytomas frequently overexpress wild-type p53, which suggests that gliomas have evolved a mechanism to subvert p53-mediated apoptosis. bcl-2 inhibits apoptosis mediated by p53, and it is expressed in several human cancers. We therefore examined a series of human gliomas to determine whether bcl-2 is expressed and whether this expression is associated with tumors which have wild-type p53. Twenty-eight...

Topics

Apoptosis
Astrocytoma
Gene Expression
Genes, p53
Glioma
Immunohistochemistry
Mutation
Paraffin Embedding
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2
Tumor Suppressor Protein p53

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PMID: 7867012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7867012-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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