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Article

VH gene segments in the mouse and human genomes.

Journal of molecular biology - 3 Sept 2004

de Bono Bernard, Madera Martin, Chothia Cyrus

Abstract excerpt

We have examined the mouse genome sequence to determine its VH gene segment repertoire. In all, 141 segments are mapped to a 3 Mb region of chromosome 12. There is evidence that 92 of these are functional in the mouse strain used for the genome sequence, C57BL/6J; 12 are functional in other mouse strains, and 37 are pseudogenes. The mouse VH gene segment repertoire is therefore twice the size of that in humans....

Topics

Amino Acid Sequence
Animals
Evolution, Molecular
Genes, Immunoglobulin
Genetic Variation
Genome
Humans
Immunoglobulin Heavy Chains
Immunoglobulin Variable Region
Likelihood Functions
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Multigene Family

Phylogeny

Sequence Alignment

Source

Identifiers

PMID: 15313612
DOI: 10.1016/j.jmb.2004.06.055

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