Article
Loss of somatostatin-like immunoreactivity in the frontal cortex of Alzheimer patients carrying the apolipoprotein epsilon 4 allele.
Neuroscience letters - 9 Oct 1998
Grouselle D, Winsky-Sommerer R, David J P, Delacourte A, Dournaud P, Epelbaum J
Abstract excerpt
We measured somatostatin-like immunoreactivity, using a radioimmunoassay which does not cross react with cortistatin-like immunoreactivity, in postmortem frontal cortex (Brodmann area 9) from 32 patients, of different apolipoprotein E genotypes, and presenting with different degrees of cognitive...
Topics
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Apolipoprotein E4
- Apolipoproteins E
- Cadaver
- Frontal Lobe
- Humans
- Osmolar Concentration
- Radioimmunoassay
- Somatostatin