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Article

Lower levels of N-acetylaspartate in multiple sclerosis patients with the apolipoprotein E epsilon4 allele.

Archives of neurology - 1 Jan 2003

Enzinger Christian, Ropele Stefan, Strasser-Fuchs Siegrid, Kapeller Peter, Schmidt Helena, Poltrum Birgit, Schmidt Reinhold, Hartung Hans-Peter, Fazekas Franz

Abstract excerpt

BACKGROUND: In multiple sclerosis (MS), the epsilon4 allele of apolipoprotein E (APOE epsilon4) has been associated with more rapid clinical worsening and more severe tissue damage on magnetic resonance imaging. OBJECTIVE: To use proton magnetic resonance spectroscopy ((1)H-MRS) to further explore the biochemical changes in the brains of patients with MS associated with APOE epsilon4. DESIGN: A 2-year clinical...

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Source

Identifiers

PMID: 12533090
DOI: 10.1001/archneur.60.1.65

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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