Article
Stage dependent effects of progesterone on motoneurons and glial cells of wobbler mouse spinal cord degeneration.
Cellular and molecular neurobiology - 1 Jan 2010
Meyer Maria, Gonzalez Deniselle Maria Claudia, Garay Laura I, Monachelli Gisella Gargiulo, Lima Analia, Roig Paulina, Guennoun Rachida, Schumacher Michael, De Nicola Alejandro F
Abstract excerpt
In the Wobbler mouse, a mutation in the Vps54 gene is accompanied by motoneuron degeneration and astrogliosis in the cervical spinal cord. Previous work has shown that these abnormalities are greatly attenuated by progesterone treatment of clinically afflicted Wobblers. However, whether progesterone is effective at all disease stages has not yet been tested. The present work used genotyped (wr/wr) Wobbler mice at...
Topics
- Animals
- Anterior Horn Cells
- Astrocytes
- Cell Count
- Choline O-Acetyltransferase
- Disease Models, Animal
- Female
- GAP-43 Protein
- Gene Expression Regulation
- Genotype
- Glial Fibrillary Acidic Protein
- Glutamate-Ammonia Ligase