Article
Electromyographical and motor performance studies in the pmn mouse model of neurodegenerative disease.
Neurobiology of disease - 1 Apr 1996
Kennel P F, Fonteneau P, Martin E, Schmidt J M, Azzouz M, Borg J, Guenet J L, Schmalbruch H, Warter J M, Poindron P
Abstract excerpt
The mouse autosomal recessive mutation progressive motor neuronopathy (pmn) results in early onset motor neuron disease with rapidly progressive hindlimb paralysis, severe muscular wasting, and death at around 6 weeks of age. This mutant provides opportunities for testing novel therapeutic strate...
Topics
- Action Potentials
- Animals
- Diaphragm
- Disease Models, Animal
- Electromyography
- Facial Nerve
- Female
- Foot Deformities, Congenital
- Genes, Recessive
- Genetic Linkage
- Hereditary Sensory and Motor Neuropathy
- Male
- Mice
- Mice, Neurologic Mutants
- Motor Activity