Article
Electromyographical and motor performance studies in the pmn mouse model of neurodegenerative disease.
Neurobiology of disease - 1 Apr 1996
Kennel P F, Fonteneau P, Martin E, Schmidt J M, Azzouz M, Borg J, Guenet J L, Schmalbruch H, Warter J M, Poindron P
Abstract excerpt
The mouse autosomal recessive mutation progressive motor neuronopathy (pmn) results in early onset motor neuron disease with rapidly progressive hindlimb paralysis, severe muscular wasting, and death at around 6 weeks of age. This mutant provides opportunities for testing novel therapeutic strategies, including the administration of trophic factors, to prevent the degeneration of diseased neurons. The...
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