Article
Rescue of angiotensinogen-knockout mice.
Biochemical and biophysical research communications - 27 Nov 1998
Ishida J, Sugiyama F, Tanimoto K, Taniguchi K, Syouji M, Takimoto E, Horiguchi H, Murakami K, Yagami K i, Fukamizu A
Abstract excerpt
Angiotensinogen, the precursor of angiotensins I and II, is a critical component of the renin-angiotensin system that plays an important role in regulating blood pressure and electrolyte homeostasis. Genetically altered mice lacking angiotensinogen (Agt-KO) showed an expected phenotype, such as marked hypotension, but unexpected ones including abnormal kidney morphology, reduced survival rates of newborns, and...
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