Article
Rescue of angiotensinogen-knockout mice.
Biochemical and biophysical research communications - 27 Nov 1998
Ishida J, Sugiyama F, Tanimoto K, Taniguchi K, Syouji M, Takimoto E, Horiguchi H, Murakami K, Yagami K i, Fukamizu A
Abstract excerpt
Angiotensinogen, the precursor of angiotensins I and II, is a critical component of the renin-angiotensin system that plays an important role in regulating blood pressure and electrolyte homeostasis. Genetically altered mice lacking angiotensinogen (Agt-KO) showed an expected phenotype, such as m...
Topics
- Angiotensin I
- Angiotensinogen
- Animals
- Hypotension
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Phenotype
- Renin-Angiotensin System
- Transgenes