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Article

Hereditary frontotemporal dementia caused by Tau gene mutations.

Brain pathology (Zurich, Switzerland) - 1 Jan 2007

van Swieten John, Spillantini Maria Grazia

Abstract excerpt

Tau protein is involved in microtubule assembly and stabilization. Filamentous deposits made of tau constitute a defining characteristic of several neurodegenerative diseases. The relevance of tau dysfunction for neurodegeneration has been clarified through the identification of mutations in the Tau gene in cases with frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Although the...

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Identifiers

PMID: 17493040
DOI: 10.1111/j.1750-3639.2007.00052.x
PMCID: PMC8095608

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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