Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tau mutations in frontotemporal dementia FTDP-17 and their relevance for Alzheimer's disease.

Biochimica et biophysica acta - 26 Jul 2000

Goedert M, Spillantini M G

Abstract excerpt

Alzheimer's disease is characterised by the degeneration of selected populations of nerve cells that develop filamentous inclusions prior to degeneration. The neuronal inclusions of Alzheimer's disease are made of the microtubule-associated protein tau, in a hyperphosphorylated state. Abundant filamentous tau inclusions are not limited to Alzheimer's disease. They are the defining neuropathological characteristic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Dementia
Share to Introns

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microtubule-Associated Proteins

Share to Microtubules

Share to Phosphoproteins

Share to Protein Isoforms

Share to tau Proteins

Source

Identifiers

PMID: 10899436
DOI: 10.1016/s0925-4439(00)00037-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tau mutations in frontotemporal dementia FTDP-17 and their relevance for Alzheimer's disease.PMID 10899436Read ↗

Tau gene mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17).Semantic proximity Read ↗

Mutations causing neurodegenerative tauopathies.Semantic proximity Read ↗

Hereditary frontotemporal dementia caused by Tau gene mutations.Semantic proximity Read ↗

Accelerated filament formation from tau protein with specific FTDP‐17 missense mutationsSemantic proximity Read ↗

Tau gene mutations: dissecting the pathogenesis of FTDP-17.Semantic proximity Read ↗

Tau mutations in familial frontotemporal dementiaSemantic proximity Read ↗

Tau gene mutations and their effectsSemantic proximity Read ↗

Tau gene mutations and neurodegeneration.Semantic proximity Read ↗

New developments in frontotemporal dementia and parkinsonism linked to chromosome 17.Semantic proximity Read ↗

FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and Tau filaments in forebrain.Semantic proximity Read ↗

FTDP-17 tau mutations decrease the susceptibility of tau to calpain I digestion.Semantic proximity Read ↗

Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.