Article
Central T cell tolerance in lupus-prone mice: influence of autoimmune background and the lpr mutation.
Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 1998
Fatenejad S, Peng S L, Disorbo O, Craft J
Abstract excerpt
Lupus-prone mice develop a systemic autoimmune disease that is dependent upon the B cell help provided by autoreactive alphabeta CD4+ T cells. Since autoreactive T cells with high affinity for self peptides are normally deleted in the thymus, their presence in these mice suggests the possibility...
Topics
- Amino Acid Sequence
- Animals
- Apoptosis
- Autoimmune Diseases
- Cell Line
- Clonal Deletion
- Columbidae
- Cytochrome c Group
- Down-Regulation
- Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
- Immune Tolerance
- Lupus Nephritis
- Lymphocyte Activation
- Mice
- Mice, Inbred C57BL
- Mice, Inbred MRL lpr
- Mice, Transgenic
- Molecular Sequence Data