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Article

T cells specific for post-translational modifications escape intrathymic tolerance induction

18 Jan 2018

Abstract excerpt

Establishing effective central tolerance requires the promiscuous expression of tissue-restricted antigens by medullary thymic epithelial cells. However, whether central tolerance also extends to post-translationally modified proteins is not clear. Here we show a mouse model of autoimmunity in which disease development is dependent on post-translational modification (PTM) of the tissue-restricted self-antigen...

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PMID: 29367624
DOI: 10.1038/s41467-017-02763-y

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